Reactome | 3CLp cleaves pp1ab

Schema > Reaction > Entries

3CLp cleaves pp1ab Show undefined attributes

authored	[InstanceEdit:9683039] Stephan, Ralf, 2020-04-14
catalystActivity	[CatalystActivity:9684361] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9684359] Stephan, Ralf, 2020-04-21
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9684340
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	3CLp cleaves pp1ab
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9684325] Maturation of replicase proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9684336] nsp1-4 cleaves itself - Homo sapiens [BlackBoxEvent:R-HSA-9684282] nsp9 forms a homodimer - Homo sapiens
input	11 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-COV-9684355] pp1ab [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9684297] Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp cleaves pp1ab
output	[EntityWithAccessionedSequence:R-COV-9684861] pp1ab-nsp1-4 [cytosol] [EntityWithAccessionedSequence:R-COV-9682216] pp1ab-nsp10 [cytosol] [EntityWithAccessionedSequence:R-COV-9678280] pp1ab-nsp12 [cytosol] [EntityWithAccessionedSequence:R-COV-9678281] pp1ab-nsp13 [cytosol] [EntityWithAccessionedSequence:R-COV-9678285] pp1ab-nsp14 [cytosol] [EntityWithAccessionedSequence:R-COV-9678288] pp1ab-nsp15 [cytosol] [EntityWithAccessionedSequence:R-COV-9678289] pp1ab-nsp16 [cytosol] [EntityWithAccessionedSequence:R-COV-9682196] pp1ab-nsp5 [cytosol] [EntityWithAccessionedSequence:R-COV-9682233] pp1ab-nsp6 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-COV-9682244] pp1ab-nsp7 [cytosol] [EntityWithAccessionedSequence:R-COV-9682242] pp1ab-nsp8 [cytosol] [EntityWithAccessionedSequence:R-COV-9682232] pp1ab-nsp9 [cytosol]
precedingEvent	[Reaction:R-HSA-9684323] 3CLp forms a homodimer - Homo sapiens [BlackBoxEvent:R-HSA-9684277] mRNA1 is translated to pp1ab - Homo sapiens
regulatedBy	[NegativeRegulation:9686287] Negative regulation by '3CLp dimer:?-Ketoamides [cytosol]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9684340
summation	[Summation:9686301] Main protease cleaves all cleavage sites of pp1a and ppa1b s... [Summation:9684353] Main protease cleaves all cleavage sites of pp1a and ppa1b s...
updateTrackers	[UpdateTracker:9776841] Update Tracker - [Reaction:9684340] 3CLp cleaves pp1ab - v74:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776841] Update Tracker - [Reaction:9684340] 3CLp cleaves pp1ab - v74:[add_removeOutput]
(precedingEvent)	[BlackBoxEvent:R-HSA-9684282] nsp9 forms a homodimer [Reaction:R-HSA-9684336] nsp1-4 cleaves itself
(hasEvent)	[Pathway:R-HSA-9684325] Maturation of replicase proteins