Reactome | activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-CFA-937070] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10238016
displayName	activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]
hasMember	[Complex:R-CFA-9823900] p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Canis familiaris [Complex:R-CFA-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Canis familiaris
inDisease	false
inferredFrom	[DefinedSet:R-HSA-936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - Homo sapiens
maxDepth	9
name	activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE
producedByEvent	[Reaction:R-CFA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Canis familiaris
schemaClass	DefinedSet
species	[Species:49646] Canis familiaris
stId	R-CFA-936970

(output)	[Reaction:R-CFA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
(input)	[Reaction:R-CFA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
(hasComponent)	[Complex:R-CFA-937070] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
(inferredTo)	[DefinedSet:R-HSA-936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]

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