Reactome | Estrogen-dependent gene expression

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Estrogen-dependent gene expression Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330689
displayName	Estrogen-dependent gene expression
eventOf	[Pathway:R-CFA-8939211] ESR-mediated signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Canis familiaris [Reaction:R-CFA-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Canis familiaris [Reaction:R-CFA-9011952] ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers - Canis familiaris [Reaction:R-CFA-9011949] KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers - Canis familiaris [BlackBoxEvent:R-CFA-9012000] NR5A2, ZNF217 and NCOA3 bind GREB1 promoter - Canis familiaris [Reaction:R-CFA-9038052] GREB1 binds ESR1:ESTG and co-activators - Canis familiaris [Reaction:R-CFA-9012315] ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene - Canis familiaris [Reaction:R-CFA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Canis familiaris [Reaction:R-CFA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Canis familiaris [Reaction:R-CFA-9009541] ESR1 binds to TFF1 gene promoter - Canis familiaris [Reaction:R-CFA-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Canis familiaris [Reaction:R-CFA-9009533] TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter - Canis familiaris [Reaction:R-CFA-9009526] CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene - Canis familiaris [Reaction:R-CFA-9023861] PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene - Canis familiaris [Reaction:R-CFA-9023860] Histone acetyltransferases are recruited to the TFF1 gene - Canis familiaris [Reaction:R-CFA-9008271] CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter - Canis familiaris [Reaction:R-CFA-9008270] NCOA1 binds ESR1:estrogen:TGFA gene - Canis familiaris [Reaction:R-CFA-9023884] NCOA1 recruits EP300 to TGFA promoter - Canis familiaris [Reaction:R-CFA-9008258] NCOA3 binds ESR1:estrogen:TFGA gene - Canis familiaris [Reaction:R-CFA-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 - Canis familiaris [Reaction:R-CFA-9011983] Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes - Canis familiaris [Reaction:R-CFA-9011984] KDM1A is recruited to MYC and BCL2 genes - Canis familiaris [Reaction:R-CFA-9011985] KDM1A demethylates H3 on MYC and BCL genes in response to estrogen - Canis familiaris [Reaction:R-CFA-9011981] EP300 is recruited to MYC and BCL2 genes - Canis familiaris [Reaction:R-CFA-8931981] RUNX1 binds ESR1 - Canis familiaris [Reaction:R-CFA-1254386] ERBB4s80 forms a complex with estrogen receptor ESR1 - Canis familiaris [Reaction:R-CFA-9023840] HATs and coactivators are recruited to the CTSD gene - Canis familiaris
inferredFrom	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Estrogen-dependent gene expression
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9018519
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8939211] ESR-mediated signaling
(inferredTo)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression

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