Reactome | KDM1A is recruited to MYC and BCL2 genes

Schema > Reaction > Entries

KDM1A is recruited to MYC and BCL2 genes Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10316389
displayName	KDM1A is recruited to MYC and BCL2 genes
eventOf	[Pathway:R-CFA-9018519] Estrogen-dependent gene expression - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9011985] KDM1A demethylates H3 on MYC and BCL genes in response to estrogen - Canis familiaris
inferredFrom	[Reaction:R-HSA-9011984] KDM1A is recruited to MYC and BCL2 genes - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-996769] KDM1A [nucleoplasm] [Complex:R-CFA-9011891] MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KDM1A is recruited to MYC and BCL2 genes
output	[Complex:R-CFA-9011901] MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm]
precedingEvent	[Reaction:R-CFA-9011983] Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9011984
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[Reaction:R-CFA-9011985] KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
(inferredTo)	[Reaction:R-HSA-9011984] KDM1A is recruited to MYC and BCL2 genes

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