Reactome | IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]

Schema > Complex > Entries

IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10313416] transmembrane receptor protein tyrosine kinase activity of IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-CFA-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10313381
displayName	IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]
hasComponent	[Complex:R-CFA-8950331] IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [EntityWithAccessionedSequence:R-CFA-629622] STAT1 [cytosol] [EntityWithAccessionedSequence:R-CFA-539044] STAT3 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8950267] IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] - Homo sapiens
maxDepth	5
name	IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3
producedByEvent	[BlackBoxEvent:R-CFA-8950518] STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex - Canis familiaris [BlackBoxEvent:R-CFA-8950441] p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-8950267
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[BlackBoxEvent:R-CFA-8950518] STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex [BlackBoxEvent:R-CFA-8950441] p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
(input)	[BlackBoxEvent:R-CFA-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
(physicalEntity)	[CatalystActivity:10313416] transmembrane receptor protein tyrosine kinase activity of IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]
(inferredTo)	[Complex:R-HSA-8950267] IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]

© 2026 Reactome

Cite Us!