Reactome | Purine salvage

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Purine salvage Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328817
displayName	Purine salvage
eventOf	[Pathway:R-CFA-8956321] Nucleotide salvage - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:160946] purine-containing compound salvage
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-109671] deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) - Canis familiaris [Reaction:R-CFA-74213] APRT catalyzes the conversion of adenine to AMP - Canis familiaris [Reaction:R-CFA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Canis familiaris [Reaction:R-CFA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Canis familiaris [Reaction:R-CFA-74207] dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) - Canis familiaris [Reaction:R-CFA-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Canis familiaris [Reaction:R-CFA-9731661] MAPDA hydrolyzes N6-methyl-dAMP to dIMP and methylamine - Canis familiaris [Reaction:R-CFA-109624] (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) - Canis familiaris [Reaction:R-CFA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Canis familiaris [Reaction:R-CFA-112034] PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosine - Canis familiaris [Reaction:R-CFA-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine - Canis familiaris [Reaction:R-CFA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Canis familiaris
inferredFrom	[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Purine salvage
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-74217
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8956321] Nucleotide salvage
(inferredTo)	[Pathway:R-HSA-74217] Purine salvage

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