Reactome | MET dimers autophosphorylate

Schema > Reaction > Entries

MET dimers autophosphorylate Show undefined attributes

catalystActivity	[CatalystActivity:10304252] protein tyrosine kinase activity of HGF:MET dimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10304256
displayName	MET dimers autophosphorylate
eventOf	[Pathway:R-CFA-6806942] MET Receptor Activation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6807008] PTPRJ dephosphorylates MET - Canis familiaris [Reaction:R-CFA-6807027] PTPN1 and PTPN2 dephosphorylate MET - Canis familiaris [Reaction:R-CFA-8874685] CBL binds MET - Canis familiaris [Reaction:R-CFA-8851866] MET binds RANBP10 - Canis familiaris [Reaction:R-CFA-8851842] MUC20 binds MET and inhibits GRB2 binding - Canis familiaris [Reaction:R-CFA-8875531] MET binds TNS4 - Canis familiaris [Reaction:R-CFA-8875523] MET binds TNS3 - Canis familiaris [Reaction:R-CFA-8851919] Activated MET binds GAB1 and GRB2 - Canis familiaris [Reaction:R-CFA-8851908] Activated MET binds GAB1 - Canis familiaris [Reaction:R-CFA-8874079] PTK2 binds activated MET - Canis familiaris [Reaction:R-CFA-8875816] STAT3 binds activated MET receptor - Canis familiaris [Reaction:R-CFA-8851888] MET binds SHC1-2 - Canis familiaris [Reaction:R-CFA-8851804] Activated MET recruits GRB2-1:SOS1 - Canis familiaris [Reaction:R-CFA-8851859] Activated MET binds RANBP9 and SOS1 - Canis familiaris
inferredFrom	[Reaction:R-HSA-6806974] MET dimers autophosphorylate - Homo sapiens
input	8 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-6806956] HGF:MET dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MET dimers autophosphorylate
output	8 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
precedingEvent	[Reaction:R-CFA-6806957] MET receptor dimerizes - Canis familiaris
regulatedBy	[NegativeRegulation:10304257] Negative regulation by 'HGF:MET dimer:TKIs [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6806974
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6806942] MET Receptor Activation
(precedingEvent)	[Reaction:R-CFA-6807008] PTPRJ dephosphorylates MET [Reaction:R-CFA-6807027] PTPN1 and PTPN2 dephosphorylate MET [Reaction:R-CFA-8874685] CBL binds MET [Reaction:R-CFA-8851866] MET binds RANBP10 [Reaction:R-CFA-8851842] MUC20 binds MET and inhibits GRB2 binding [Reaction:R-CFA-8875531] MET binds TNS4 [Reaction:R-CFA-8875523] MET binds TNS3 [Reaction:R-CFA-8851919] Activated MET binds GAB1 and GRB2 [Reaction:R-CFA-8851908] Activated MET binds GAB1 [Reaction:R-CFA-8874079] PTK2 binds activated MET [Reaction:R-CFA-8875816] STAT3 binds activated MET receptor [Reaction:R-CFA-8851888] MET binds SHC1-2 [Reaction:R-CFA-8851804] Activated MET recruits GRB2-1:SOS1 [Reaction:R-CFA-8851859] Activated MET binds RANBP9 and SOS1
(inferredTo)	[Reaction:R-HSA-6806974] MET dimers autophosphorylate

Cite Us!