Reactome | Activated MET binds RANBP9 and SOS1

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Activated MET binds RANBP9 and SOS1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10307126
displayName	Activated MET binds RANBP9 and SOS1
eventOf	[Pathway:R-CFA-8851805] MET activates RAS signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Canis familiaris
inferredFrom	[Reaction:R-HSA-8851859] Activated MET binds RANBP9 and SOS1 - Homo sapiens
input	[Complex:R-CFA-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] [EntityWithAccessionedSequence:R-CFA-374586] RANBP9 [cytosol] [EntityWithAccessionedSequence:R-CFA-64847] SOS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated MET binds RANBP9 and SOS1
output	[Complex:R-CFA-8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-CFA-6806974] MET dimers autophosphorylate - Canis familiaris
regulatedBy	[NegativeRegulation:10307127] Negative regulation by 'HGF:p-4Y-MET dimer:RANBP10 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8851859
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8851805] MET activates RAS signaling
(precedingEvent)	[Reaction:R-CFA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
(inferredTo)	[Reaction:R-HSA-8851859] Activated MET binds RANBP9 and SOS1