Reactome | MUC20 binds MET and inhibits GRB2 binding

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MUC20 binds MET and inhibits GRB2 binding Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10307118
displayName	MUC20 binds MET and inhibits GRB2 binding
eventOf	[Pathway:R-CFA-8851805] MET activates RAS signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8851842] MUC20 binds MET and inhibits GRB2 binding - Homo sapiens
input	[Complex:R-CFA-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] [EntityWithAccessionedSequence:R-CFA-8851833] MUC20 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MUC20 binds MET and inhibits GRB2 binding
output	[Complex:R-CFA-8851839] HGF:p-4Y MET dimer:MUC20 [plasma membrane]
precedingEvent	[Reaction:R-CFA-6806974] MET dimers autophosphorylate - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8851842
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8851805] MET activates RAS signaling
(inferredTo)	[Reaction:R-HSA-8851842] MUC20 binds MET and inhibits GRB2 binding

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