Reactome | Nonhomologous End-Joining (NHEJ)

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Nonhomologous End-Joining (NHEJ) Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331317
displayName	Nonhomologous End-Joining (NHEJ)
eventOf	[Pathway:R-CFA-5693532] DNA Double-Strand Break Repair - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17665] double-strand break repair via nonhomologous end joining
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-5686685] RIF1 and PAX1IP bind TP53BP1 at DNA DSBs - Canis familiaris [Reaction:R-CFA-5693615] Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis - Canis familiaris [Reaction:R-CFA-5686900] TP53BP1 recruits DCLRE1C to ATM - Canis familiaris [Reaction:R-CFA-5686704] Activated ATM phosphorylates DCLRE1C - Canis familiaris [Reaction:R-CFA-5693575] DNA-PKcs autophosphorylates - Canis familiaris [Reaction:R-CFA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Canis familiaris [Reaction:R-CFA-5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs - Canis familiaris [Reaction:R-CFA-5693533] DCLRE1C (ARTEMIS) processes DNA DSB ends - Canis familiaris [Reaction:R-CFA-5693578] TDP1 and TDP2 process unligatable DSB ends - Canis familiaris [Reaction:R-CFA-5693574] XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ - Canis familiaris [Reaction:R-CFA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Canis familiaris
inferredFrom	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Nonhomologous End-Joining (NHEJ)
precedingEvent	[Pathway:R-CFA-5693606] DNA Double Strand Break Response - Canis familiaris
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-5693571
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5693532] DNA Double-Strand Break Repair
(hasEncapsulatedEvent)	[Pathway:R-CFA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) [Pathway:R-CFA-5693606] DNA Double Strand Break Response
(inferredTo)	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ)

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