Reactome | MKL1 translocates from cytosol to the nucleus

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MKL1 translocates from cytosol to the nucleus Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10292316
displayName	MKL1 translocates from cytosol to the nucleus
eventOf	[Pathway:R-CFA-5663220] RHO GTPases Activate Formins - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5665998] MKL1 binds SRF - Canis familiaris
inferredFrom	[Reaction:R-HSA-5665999] MKL1 translocates from cytosol to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-5665975] MRTFA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MKL1 translocates from cytosol to the nucleus
output	[EntityWithAccessionedSequence:R-CFA-3900220] MRTFA [nucleoplasm]
precedingEvent	[Reaction:R-CFA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5665999
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-CFA-5665998] MKL1 binds SRF
(inferredTo)	[Reaction:R-HSA-5665999] MKL1 translocates from cytosol to the nucleus

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