Reactome | MKL1 binds SRF

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MKL1 binds SRF Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10292314
displayName	MKL1 binds SRF
eventOf	[Pathway:R-CFA-5663220] RHO GTPases Activate Formins - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5666008] SCAI binds SRF:MKL1 - Canis familiaris
inferredFrom	[Reaction:R-HSA-5665998] MKL1 binds SRF - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-3900220] MRTFA [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-5666000] SRF [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MKL1 binds SRF
output	[Complex:R-CFA-5666002] SRF:MKL1 [nucleoplasm]
precedingEvent	[Reaction:R-CFA-5665999] MKL1 translocates from cytosol to the nucleus - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5665998
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-CFA-5666008] SCAI binds SRF:MKL1
(inferredTo)	[Reaction:R-HSA-5665998] MKL1 binds SRF