Reactome | PTK2B binds JAK3

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10259976
displayName	PTK2B binds JAK3
eventOf	[Pathway:R-CFA-9020558] Interleukin-2 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-508451] PTK2B is phosphorylated - Canis familiaris
inferredFrom	[Reaction:R-HSA-508513] PTK2B binds JAK3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-451893] JAK3 [cytosol] [EntityWithAccessionedSequence:R-CFA-390932] PTK2B [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTK2B binds JAK3 Pyk2 associates with Jak3
output	[Complex:R-CFA-508512] JAK3:PYK2 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-508513
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-9020558] Interleukin-2 signaling
(precedingEvent)	[BlackBoxEvent:R-CFA-508451] PTK2B is phosphorylated
(inferredTo)	[Reaction:R-HSA-508513] PTK2B binds JAK3

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