Reactome | Interleukin-2 signaling

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Interleukin-2 signaling Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330445
displayName	Interleukin-2 signaling
eventOf	[Pathway:R-CFA-451927] Interleukin-2 family signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2266257] interleukin-2-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-450054] Interleukin-2 receptor alpha binds interleukin-2 - Canis familiaris [Reaction:R-CFA-451900] IL2RB binds JAK1 - Canis familiaris [Reaction:R-CFA-450027] Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta - Canis familiaris [Reaction:R-CFA-9679028] JAK3 binds JAK3 inhibitors - Canis familiaris [Reaction:R-CFA-451942] Within the IL-2R complex JAK3 phosphorylates JAK1 - Canis familiaris [Reaction:R-CFA-452122] JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB - Canis familiaris [Reaction:R-CFA-452091] Phosphorylation of IL2RB Y338 enables SHC recruitment - Canis familiaris [Reaction:R-CFA-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment - Canis familiaris [Reaction:R-CFA-452100] SHC1 bound to IL2 receptor is phosphorylated - Canis familiaris [Reaction:R-CFA-452097] Recruited STAT5 is phosphorylated - Canis familiaris [Reaction:R-CFA-919404] Phosphorylated STAT5 is released - Canis familiaris [Reaction:R-CFA-508292] SYK binds IL2RB - Canis familiaris [Reaction:R-CFA-508282] SYK is a substrate for JAK1 - Canis familiaris [Reaction:R-CFA-508513] PTK2B binds JAK3 - Canis familiaris [BlackBoxEvent:R-CFA-508451] PTK2B is phosphorylated - Canis familiaris
inferredFrom	[Pathway:R-HSA-9020558] Interleukin-2 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-2 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9020558
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-451927] Interleukin-2 family signaling
(inferredTo)	[Pathway:R-HSA-9020558] Interleukin-2 signaling

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