Reactome | Phosphorylation of LIMK-1 by PAK

Schema > Reaction > Entries

Phosphorylation of LIMK-1 by PAK Show undefined attributes

catalystActivity	[CatalystActivity:10253932] protein serine/threonine kinase activity of Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10253934
displayName	Phosphorylation of LIMK-1 by PAK
eventOf	[Pathway:R-CFA-399954] Sema3A PAK dependent Axon repulsion - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-419645] Dimerization of LIMK1 by Hsp90 - Canis familiaris
inferredFrom	[Reaction:R-HSA-399952] Phosphorylation of LIMK-1 by PAK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-CFA-397785] LIMK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of LIMK-1 by PAK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-CFA-399816] phospho-LIMK1 [cytosol]
precedingEvent	[Reaction:R-CFA-399939] Autophosphorylation of PAK - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-399952
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-399954] Sema3A PAK dependent Axon repulsion
(precedingEvent)	[Reaction:R-CFA-419645] Dimerization of LIMK1 by Hsp90
(inferredTo)	[Reaction:R-HSA-399952] Phosphorylation of LIMK-1 by PAK

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