Reactome | CTNNB1 [nucleoplasm]

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CTNNB1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-4411394] TCF/LEF:CTNNB1 [nucleoplasm] - Canis familiaris [Complex:R-CFA-5626915] CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] - Canis familiaris [Complex:R-CFA-201917] TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] - Canis familiaris [Complex:R-CFA-3361754] TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-3772430] CTNNBIP1 binds beta-catenin - Canis familiaris [Reaction:R-CFA-5368580] CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression - Canis familiaris [Reaction:R-CFA-5626938] Beta-catenin binds SOX proteins - Canis familiaris [Reaction:R-CFA-3769383] CBY1 binds beta-catenin - Canis familiaris [Reaction:R-CFA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10244810
displayName	CTNNB1 [nucleoplasm]
endCoordinate	781
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	CTNNB1 CTNNB1 A0A8I3NUM7
producedByEvent	[BlackBoxEvent:R-CFA-201669] Beta-catenin translocates to the nucleus - Canis familiaris [Reaction:R-CFA-8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3NUM7] UniProt:A0A8I3NUM7
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-3451168
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-CFA-4411394] TCF/LEF:CTNNB1 [nucleoplasm] [Complex:R-CFA-3772415] CTNNBIP1:CTNNB1 [nucleoplasm] [Complex:R-CFA-5368504] CTNNB1:CHD8 [nucleoplasm] [Complex:R-CFA-5626915] CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] [Complex:R-CFA-3769380] CBY1:CTNNB1 [nucleoplasm] [Complex:R-CFA-3769358] pS20-CBY1:CTNNB1 [nucleoplasm] [Complex:R-CFA-4411380] p-TCF/LEF:CTNNB1 [nucleoplasm] [Complex:R-CFA-201917] TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] [Complex:R-CFA-3361369] TCF/LEF:CTNNB1:BCL9:PYGO:MLL2:MEN1 complex [nucleoplasm] [Complex:R-CFA-3361756] APC:CTBP:CTNNB1:BTRC [nucleoplasm] [Complex:R-CFA-3361754] TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] [Complex:R-CFA-3299548] TCF/LEF:CTNNB1 [nucleoplasm] [Complex:R-CFA-8951429] CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] [Complex:R-CFA-4411378] TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm] [Complex:R-CFA-4411397] TCF/LEF:CTNNB1 [nucleoplasm]
(input)	[Reaction:R-CFA-3772430] CTNNBIP1 binds beta-catenin [Reaction:R-CFA-5368580] CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression [Reaction:R-CFA-5626938] Beta-catenin binds SOX proteins [Reaction:R-CFA-3769383] CBY1 binds beta-catenin [Reaction:R-CFA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF
(output)	[BlackBoxEvent:R-CFA-201669] Beta-catenin translocates to the nucleus [Reaction:R-CFA-8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm]

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