Reactome | CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression

Schema > Reaction > Entries

CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10288091
displayName	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression
eventOf	[Pathway:R-CFA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily - Canis familiaris [Pathway:R-CFA-3769402] Deactivation of the beta-catenin transactivating complex - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5368580] CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-3221598] CHD8 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-3451168] CTNNB1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression
output	[Complex:R-CFA-5368504] CTNNB1:CHD8 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-CFA-201669] Beta-catenin translocates to the nucleus - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5368580
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily [Pathway:R-CFA-3769402] Deactivation of the beta-catenin transactivating complex
(inferredTo)	[Reaction:R-HSA-5368580] CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression

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