Reactome | INS [endoplasmic reticulum lumen]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:17957] endoplasmic reticulum lumen
consumedByEvent	[BlackBoxEvent:R-CFA-265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10248127
displayName	INS [endoplasmic reticulum lumen]
endCoordinate	110
hasModifiedResidue	[IntraChainCrosslinkedResidue:10248113] Intra-chain Crosslink via L-cystine (cross-link) at 31 and 96 (in Homo sapiens) [IntraChainCrosslinkedResidue:10248114] Intra-chain Crosslink via L-cystine (cross-link) at 43 and 109 (in Homo sapiens) [IntraChainCrosslinkedResidue:10230928] Intra-chain Crosslink via L-cystine (cross-link) at 95 and 100 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-265075] 6xHC-INS(25-110) [endoplasmic reticulum lumen] - Homo sapiens
maxDepth	1
name	INS 6xHC-INS(25-110) P01321
producedByEvent	[Reaction:R-CFA-264997] P4HB mediates disulfide bond formation in Proinsulin - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:P01321] UniProt:P01321
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-265075
startCoordinate	25

(input)	[BlackBoxEvent:R-CFA-265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi
(output)	[Reaction:R-CFA-264997] P4HB mediates disulfide bond formation in Proinsulin
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-265075] 6xHC-INS(25-110) [endoplasmic reticulum lumen]

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