Reactome | P4HB mediates disulfide bond formation in Proinsulin

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P4HB mediates disulfide bond formation in Proinsulin Show undefined attributes

catalystActivity	[CatalystActivity:10248128] protein-disulfide reductase activity of HC53,56-P4HB [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10248130
displayName	P4HB mediates disulfide bond formation in Proinsulin
eventOf	[Pathway:R-CFA-264876] Insulin processing - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9817575] ERO1B oxidizes P4HB - Canis familiaris [BlackBoxEvent:R-CFA-265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi - Canis familiaris
inferredFrom	[Reaction:R-HSA-264997] P4HB mediates disulfide bond formation in Proinsulin - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-264893] INS [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-CFA-3341287] P4HB [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	P4HB mediates disulfide bond formation in Proinsulin Oxidation of cysteine to cystine in Proinsulin
output	[EntityWithAccessionedSequence:R-CFA-265075] INS [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-CFA-174692] P4HB [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-264997
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-264876] Insulin processing
(precedingEvent)	[Reaction:R-CFA-9817575] ERO1B oxidizes P4HB [BlackBoxEvent:R-CFA-265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi
(inferredTo)	[Reaction:R-HSA-264997] P4HB mediates disulfide bond formation in Proinsulin

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