Reactome | phospho-PLCG1 [plasma membrane]

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CFA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] - Canis familiaris [Complex:R-CFA-9699992] Active ALK:p-4Y PLCG1 [plasma membrane] - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10245294
displayName	phospho-PLCG1 [plasma membrane]
endCoordinate	1290
hasModifiedResidue	[ModifiedResidue:10245292] O4'-phospho-L-tyrosine at 472 (in Homo sapiens) [ModifiedResidue:10245248] O4'-phospho-L-tyrosine at 771 (in Homo sapiens) [ModifiedResidue:10245249] O4'-phospho-L-tyrosine at 783 (in Homo sapiens) [ModifiedResidue:10245250] O4'-phospho-L-tyrosine at 1253 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-CFA-2685653] p-4Y-PLCG [plasma membrane] - Canis familiaris
name	phospho-PLCG1 p-4Y-PLCG1 A0A8I3SCI7
producedByEvent	[BlackBoxEvent:R-CFA-9034855] Activated PCLG1 dissociates from NTRK3 - Canis familiaris [BlackBoxEvent:R-CFA-9026894] Activated PCLG1 dissociates from NTRK2 - Canis familiaris [Reaction:R-CFA-5654169] p-4Y-PLCG1 dissociates from activated FGFR4 - Canis familiaris [Reaction:R-CFA-1524182] Activated PLC gamma dissociates from the PDGF receptor - Canis familiaris [Reaction:R-CFA-212713] Active PLC-gamma1 dissociates from EGFR - Canis familiaris [Reaction:R-CFA-5654157] p-4Y-PLCG1 dissociates from activated FGFR2 - Canis familiaris [Reaction:R-CFA-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Canis familiaris [Reaction:R-CFA-5654165] p-4Y-PLCG1 dissociates from activated FGFR1 - Canis familiaris [Reaction:R-CFA-5654148] p-4Y-PLCG1 dissociates from activated FGFR3 - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3SCI7] UniProt:A0A8I3SCI7
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-167679
startCoordinate	2

(hasComponent)	[Complex:R-CFA-9699992] Active ALK:p-4Y PLCG1 [plasma membrane] [Complex:R-CFA-9034820] NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-9026576] BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-CFA-5654168] activated FGFR4:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-5654150] activated FGFR2:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-4420110] VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-5654154] activated FGFR1:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-5654156] activated FGFR3:p-4Y-PLCG1 [plasma membrane] [Complex:R-CFA-1524184] PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] [Complex:R-CFA-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
(hasMember)	[DefinedSet:R-CFA-2685653] p-4Y-PLCG [plasma membrane] [DefinedSet:R-CFA-2029095] p-PLCG [plasma membrane]
(output)	[BlackBoxEvent:R-CFA-9034855] Activated PCLG1 dissociates from NTRK3 [BlackBoxEvent:R-CFA-9026894] Activated PCLG1 dissociates from NTRK2 [Reaction:R-CFA-5654169] p-4Y-PLCG1 dissociates from activated FGFR4 [Reaction:R-CFA-5654157] p-4Y-PLCG1 dissociates from activated FGFR2 [Reaction:R-CFA-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM [Reaction:R-CFA-5654165] p-4Y-PLCG1 dissociates from activated FGFR1 [Reaction:R-CFA-5654148] p-4Y-PLCG1 dissociates from activated FGFR3 [Reaction:R-CFA-1524182] Activated PLC gamma dissociates from the PDGF receptor [Reaction:R-CFA-212713] Active PLC-gamma1 dissociates from EGFR
(activeUnit)	[CatalystActivity:10245319] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-PLCG [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane]

phospho-PLCG1 [plasma membrane] Show undefined attributes

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