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phospho-PLCG1 [plasma membrane]
Stable Identifier
R-CFA-167679
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
p-4Y-PLCG1, A0A8I3SCI7
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
TCR signaling (Canis familiaris)
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
p-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-4Y-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Release of p-PLCG1 (Canis familiaris)
p-4Y-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-4Y-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-4Y-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-4Y-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
Phosphorylation and activation of PLCG (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
p-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Release of PLCG from FCGR (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
p-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-PLCG [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK phosphorylates PLCG1 (Canis familiaris)
Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR interacts with phospholipase C-gamma (Canis familiaris)
Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
Phospholipase C-mediated cascade: FGFR1 (Canis familiaris)
Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
Phospholipase C-mediated cascade; FGFR2 (Canis familiaris)
Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
Phospholipase C-mediated cascade; FGFR3 (Canis familiaris)
Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
Phospholipase C-mediated cascade; FGFR4 (Canis familiaris)
Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK2 (TRKB) (Canis familiaris)
Activated NTRK2 signals through PLCG1 (Canis familiaris)
Activated PCLG1 dissociates from NTRK2 (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by NTRK3 (TRKC) (Canis familiaris)
Activated NTRK3 signals through PLCG1 (Canis familiaris)
Activated PCLG1 dissociates from NTRK3 (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Phosphorylation of PLCgamma by PDGFR (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFR2 mediated cell proliferation (Canis familiaris)
PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
SFKs phosphorylate PLCG1 (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
phospho-PLCG1 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3SCI7
Gene Names
PLCG1
Reference Genes
BioGPS Gene:485874 PLCG1
ENSEMBL:ENSCAFG00845030031.1
KEGG:cfa:485874 PLCG1
Monarch:485874 PLCG1
NCBI Gene:485874 PLCG1
UCSC:A0A8I3SCI7 PLCG1
Reference Transcript
RefSeq:XM_038433833.1 PLCG1
RefSeq:XM_038457654.1 PLCG1
RefSeq:XM_038572317.1 PLCG1
Other Identifiers
485874
Cfa.10234.1.A1_at
CfaAffx.14355.1.S1_s_at
GO:0001726
GO:0004435
GO:0004629
GO:0005168
GO:0005509
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0007165
GO:0007173
GO:0008081
GO:0008180
GO:0009395
GO:0010634
GO:0016042
GO:0016477
GO:0016787
GO:0019722
GO:0019901
GO:0030027
GO:0032587
GO:0035556
GO:0042995
GO:0043536
GO:0045766
GO:0046488
GO:0046872
GO:0048015
GO:0048870
GO:0051209
GO:0051281
GO:0055085
GO:0071364
GO:1905564
GO:2000353
Participates
as a component of
Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
as a member of
p-4Y-PLCG [plasma membrane] (Canis familiaris)
p-PLCG [plasma membrane] (Canis familiaris)
as an output of
Activated PCLG1 dissociates from NTRK3 (Canis familiaris)
Activated PCLG1 dissociates from NTRK2 (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)
PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)
Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)
Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
Other forms of this molecule
phospho-PLCG1 [plasma membrane]
phospho-PLCG1 [cytosol]
PLCG1 [plasma membrane]
PLCG1 [cytosol]
Inferred From
p-4Y-PLCG1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 472 (in Homo sapiens)
Coordinate
472
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771 (in Homo sapiens)
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 783 (in Homo sapiens)
Coordinate
783
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1253 (in Homo sapiens)
Coordinate
1253
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_038313582.1
,
XP_038428245.1
,
XP_038289761.1
ENSEMBL
ENSCAFP00845041776
,
ENSCAFG00845030031
,
ENSCAFT00845053205
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