Reactome | G-protein beta-gamma complex [plasma membrane]

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G-protein beta-gamma complex [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CFA-398037] G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] - Canis familiaris [Complex:R-CFA-1013017] GABA B receptor G-protein beta-gamma complex [plasma membrane] - Canis familiaris [Complex:R-CFA-3965394] WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-398040] Gbeta:gamma activation of PLC beta - Canis familiaris [Reaction:R-CFA-392295] Gbeta:gamma recruits PI3K gamma - Canis familiaris [Reaction:R-CFA-167433] G-protein beta-gamma subunits rebind the alpha-GDP subunit - Canis familiaris [Reaction:R-CFA-1013013] Association of GABA B receptor with G protein beta-gamma subunits - Canis familiaris [Reaction:R-CFA-750993] Inactive G alpha (q) reassociates with G beta:gamma - Canis familiaris [Reaction:R-CFA-750988] Inactive G alpha (z) reassociates with G beta:gamma - Canis familiaris [Reaction:R-CFA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Canis familiaris [Reaction:R-CFA-751001] Inactive G alpha (i) reassociates with G beta:gamma - Canis familiaris [Reaction:R-CFA-751039] Inactive G alpha (12/13) reassociates with G beta:gamma - Canis familiaris [Reaction:R-CFA-751039] Inactive G alpha (12/13) reassociates with G beta:gamma - Canis familiaris [Reaction:R-CFA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10234338
displayName	G-protein beta-gamma complex [plasma membrane]
hasComponent	[CandidateSet:R-CFA-6814413] G-protein beta subunit [cytosol] [CandidateSet:R-CFA-167442] G-protein gamma subunit [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] - Homo sapiens
maxDepth	3
name	G-protein beta-gamma complex
positivelyRegulates	[PositiveRegulation:10317465] Positive regulation by 'G-protein beta-gamma complex [plasma membrane]'
producedByEvent	[Reaction:R-CFA-418576] Dissociation of the P2Y purinoceptor 1:Gq complex - Canis familiaris [Reaction:R-CFA-392202] Dissociation of the P2Y purinoceptor 12:Gi complex - Canis familiaris [Reaction:R-CFA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Canis familiaris [Reaction:R-CFA-749454] The Ligand:GPCR:Gi complex dissociates - Canis familiaris [Reaction:R-CFA-749452] The Ligand:GPCR:Gq complex dissociates - Canis familiaris [Reaction:R-CFA-751024] The Ligand:GPCR:Gz complex dissociates - Canis familiaris [Reaction:R-CFA-3965447] G-protein subunits dissociate from WNT:FZD complex - Canis familiaris [Reaction:R-CFA-397835] Thrombin-activated PARs:Gq (active) dissociate - Canis familiaris [Reaction:R-CFA-112271] The receptor:G-protein complex dissociates - Canis familiaris [Reaction:R-CFA-8982640] G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) - Canis familiaris [Reaction:R-CFA-428752] Dissociation of the TP:Gq complex - Canis familiaris [Reaction:R-CFA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Canis familiaris [Reaction:R-CFA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Canis familiaris [Reaction:R-CFA-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex - Canis familiaris [Reaction:R-CFA-8964317] PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex - Canis familiaris [Reaction:R-CFA-751019] The Ligand:GPCR:G12/13 complex dissociates - Canis familiaris [Reaction:R-CFA-751019] The Ligand:GPCR:G12/13 complex dissociates - Canis familiaris [Reaction:R-CFA-428918] Dissociation of the TP:G13 complex - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-167434
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-CFA-1013017] GABA B receptor G-protein beta-gamma complex [plasma membrane] [Complex:R-CFA-398037] G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] [Complex:R-CFA-114547] Heterotrimeric G-protein G12 (active) [plasma membrane] [Complex:R-CFA-398074] Heterotrimeric G-protein G13 (active) [plasma membrane] [Complex:R-CFA-114551] Heterotrimeric G-protein G12 (inactive) [plasma membrane] [Complex:R-CFA-398072] Heterotrimeric G-protein G13 (inactive) [plasma membrane] [Complex:R-CFA-392168] Heterotrimeric G-protein Gi (active) [plasma membrane] [Complex:R-CFA-392165] Heterotrimeric G-protein Gi (inactive) [plasma membrane] [Complex:R-CFA-167439] G protein-GTP [plasma membrane] [Complex:R-CFA-114557] Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] [Complex:R-CFA-392005] Heterotrimeric G-protein Gz (active) [plasma membrane] [Complex:R-CFA-391985] Heterotrimeric G-protein Gz (inactive) [plasma membrane] [Complex:R-CFA-3965394] WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] [Complex:R-CFA-3965398] Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] [Complex:R-CFA-392844] Heterotrimeric G-protein Gs (active) [plasma membrane] [Complex:R-CFA-391179] Heterotrimeric G-protein Gs (inactive) [plasma membrane] [Complex:R-CFA-392293] G-protein beta-gamma:PI3K gamma [plasma membrane] [Complex:R-CFA-9014575] G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] [Complex:R-CFA-8964249] PIP3:BTK:G-protein beta-gamma complex [plasma membrane] [Complex:R-CFA-420877] G-alpha(t)-GDP:G-beta-gamma [plasma membrane] [Complex:R-CFA-167418] G protein-GDP complex [plasma membrane] [Complex:R-CFA-9006063] G-alpha(t)-GTP:G-beta-gamma [plasma membrane]
(input)	[Reaction:R-CFA-1013013] Association of GABA B receptor with G protein beta-gamma subunits [Reaction:R-CFA-750993] Inactive G alpha (q) reassociates with G beta:gamma [Reaction:R-CFA-398040] Gbeta:gamma activation of PLC beta [Reaction:R-CFA-392295] Gbeta:gamma recruits PI3K gamma [Reaction:R-CFA-750988] Inactive G alpha (z) reassociates with G beta:gamma [Reaction:R-CFA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-CFA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-CFA-167433] G-protein beta-gamma subunits rebind the alpha-GDP subunit [Reaction:R-CFA-751001] Inactive G alpha (i) reassociates with G beta:gamma [Reaction:R-CFA-751039] Inactive G alpha (12/13) reassociates with G beta:gamma
(output)	[Reaction:R-CFA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors [Reaction:R-CFA-428752] Dissociation of the TP:Gq complex [Reaction:R-CFA-751019] The Ligand:GPCR:G12/13 complex dissociates [Reaction:R-CFA-397891] Thrombin-activated PARs:G12/13 (active) dissociate [Reaction:R-CFA-418576] Dissociation of the P2Y purinoceptor 1:Gq complex [Reaction:R-CFA-749454] The Ligand:GPCR:Gi complex dissociates [Reaction:R-CFA-749452] The Ligand:GPCR:Gq complex dissociates [Reaction:R-CFA-751024] The Ligand:GPCR:Gz complex dissociates [Reaction:R-CFA-3965447] G-protein subunits dissociate from WNT:FZD complex [Reaction:R-CFA-397835] Thrombin-activated PARs:Gq (active) dissociate [Reaction:R-CFA-392202] Dissociation of the P2Y purinoceptor 12:Gi complex [Reaction:R-CFA-428918] Dissociation of the TP:G13 complex [Reaction:R-CFA-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex [Reaction:R-CFA-8964317] PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex [Reaction:R-CFA-112271] The receptor:G-protein complex dissociates [Reaction:R-CFA-8982640] G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
(inferredTo)	[Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane]
(regulator)	[PositiveRegulation:10317465] Positive regulation by 'G-protein beta-gamma complex [plasma membrane]'

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