Reactome | Initial triggering of complement

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Initial triggering of complement Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329363
displayName	Initial triggering of complement
eventOf	[Pathway:R-CFA-166658] Complement cascade - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23216] complement activation
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-CFA-166786] Creation of C4 and C2 activators - Canis familiaris [Reaction:R-CFA-981713] C4b binds to cell surface - Canis familiaris [Reaction:R-CFA-166795] Formation of Classical C3 convertase (C4b:C2a complex) - Canis familiaris [Pathway:R-CFA-173736] Alternative complement activation - Canis familiaris
inferredFrom	[Pathway:R-HSA-166663] Initial triggering of complement - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	Initial triggering of complement
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-166663
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-166658] Complement cascade
(inferredTo)	[Pathway:R-HSA-166663] Initial triggering of complement

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