Reactome | Formation of Classical C3 convertase (C4b:C2a complex)

Schema > Reaction > Entries

Formation of Classical C3 convertase (C4b:C2a complex) Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10238085
displayName	Formation of Classical C3 convertase (C4b:C2a complex)
eventOf	[Pathway:R-CFA-166663] Initial triggering of complement - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-981621] C3 convertases spontaneously dissociate - Canis familiaris [Reaction:R-CFA-977375] CR1 binds C3bBb/C4bC2a - Canis familiaris [Reaction:R-CFA-166817] Cleavage of C3 by C3 convertases - Canis familiaris [Reaction:R-CFA-981535] CD55 (DAF) binds C3bBb, C4bC2a - Canis familiaris
inferredFrom	[Reaction:R-HSA-166795] Formation of Classical C3 convertase (C4b:C2a complex) - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-166780] C2 [extracellular region] [Complex:R-CFA-981716] Cell surface:C4b [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of Classical C3 convertase (C4b:C2a complex)
output	[Complex:R-CFA-166784] Cell surface:C4b:C2a [plasma membrane]
precedingEvent	[Reaction:R-CFA-981713] C4b binds to cell surface - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-166795
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-981621] C3 convertases spontaneously dissociate [Reaction:R-CFA-981535] CD55 (DAF) binds C3bBb, C4bC2a [Reaction:R-CFA-977375] CR1 binds C3bBb/C4bC2a [Reaction:R-CFA-166817] Cleavage of C3 by C3 convertases
(hasEvent)	[Pathway:R-CFA-166663] Initial triggering of complement
(inferredTo)	[Reaction:R-HSA-166795] Formation of Classical C3 convertase (C4b:C2a complex)