Reactome | Creation of C4 and C2 activators

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329493
displayName	Creation of C4 and C2 activators
eventOf	[Pathway:R-CFA-166663] Initial triggering of complement - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-CFA-166662] Lectin pathway of complement activation - Canis familiaris [Pathway:R-CFA-173623] Classical antibody-mediated complement activation - Canis familiaris
inferredFrom	[Pathway:R-HSA-166786] Creation of C4 and C2 activators - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Creation of C4 and C2 activators
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-166786
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-166663] Initial triggering of complement
(inferredTo)	[Pathway:R-HSA-166786] Creation of C4 and C2 activators

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