Reactome | PDPK1 binds PIP3

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10106046
displayName	PDPK1 binds PIP3
eventOf	[Pathway:R-CFA-165158] Activation of AKT2 - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-109701] PDPK1 binds PIP3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-61459] PDPK1 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
name	PDPK1 binds PIP3
output	[Complex:R-CFA-109697] PDPK1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-CFA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Canis familiaris
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-109701
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-165158] Activation of AKT2
(inferredTo)	[Reaction:R-HSA-109701] PDPK1 binds PIP3