Reactome | PDPK1:PIP3 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10300105] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CFA-9632853] PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] - Canis familiaris [Complex:R-CFA-437184] PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10233416
displayName	PDPK1:PIP3 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-CFA-61459] PDPK1 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-109697] PDPK1:PIP3 [plasma membrane] - Homo sapiens [Complex:R-HSA-377179] PDPK1:PIP3 [plasma membrane] - Homo sapiens
maxDepth	2
name	PDPK1:PIP3
producedByEvent	[Reaction:R-CFA-109701] PDPK1 binds PIP3 - Canis familiaris [Reaction:R-CFA-2316429] PIP3 recruits PDPK1 to the membrane - Canis familiaris [Reaction:R-CFA-5623667] PDPK1 phosphorylates PKN1,2,3 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-109697
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-CFA-9632853] PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] [Complex:R-CFA-437184] PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] [Complex:R-CFA-5623637] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane]
(output)	[Reaction:R-CFA-109701] PDPK1 binds PIP3 [Reaction:R-CFA-5623667] PDPK1 phosphorylates PKN1,2,3 [Reaction:R-CFA-2316429] PIP3 recruits PDPK1 to the membrane
(inferredTo)	[Complex:R-HSA-109697] PDPK1:PIP3 [plasma membrane] [Complex:R-HSA-377179] PDPK1:PIP3 [plasma membrane]
(physicalEntity)	[CatalystActivity:10300105] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
(activeUnit)	[CatalystActivity:10289813] protein serine/threonine kinase activity of RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane]
(input)	[Reaction:R-CFA-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3