Reactome | uba-1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-CEL-947628] E2 Ubiquitin-conjugating enzyme [cytosol] - Caenorhabditis elegans
catalystActivities	[CatalystActivity:10946209] ISG15 activating enzyme activity of UBA7 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CEL-1169390] ISG15:UBA7 [cytosol] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-1169397] Activation of ISG15 by UBA7 E1 enzyme - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10943693
displayName	uba-1 [cytosol]
endCoordinate	1012
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-936550] UBA7 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-CEL-936554] E2 enzymes UbcH8/UBE1L [cytosol] - Caenorhabditis elegans
name	uba-1 UBA7 Q27481
producedByEvent	[Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Caenorhabditis elegans [Reaction:R-CEL-9927247] ISGylation of DDX58 (RIG-I) - Caenorhabditis elegans
referenceEntity	[ReferenceGeneProduct:uniprot:Q27481] UniProt:Q27481
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-936550
startCoordinate	1

(output)	[Reaction:R-CEL-9927247] ISGylation of DDX58 (RIG-I) [Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8)
(hasMember)	[DefinedSet:R-CEL-936554] E2 enzymes UbcH8/UBE1L [cytosol]
(input)	[Reaction:R-CEL-1169397] Activation of ISG15 by UBA7 E1 enzyme
(physicalEntity)	[CatalystActivity:10946209] ISG15 activating enzyme activity of UBA7 [cytosol]
(hasComponent)	[Complex:R-CEL-1169390] ISG15:UBA7 [cytosol]
(hasCandidate)	[CandidateSet:R-CEL-947628] E2 Ubiquitin-conjugating enzyme [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-936550] UBA7 [cytosol]

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