Reactome | Activation of ISG15 by UBA7 E1 enzyme

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Activation of ISG15 by UBA7 E1 enzyme Show undefined attributes

catalystActivity	[CatalystActivity:10946209] ISG15 activating enzyme activity of UBA7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10946211
displayName	Activation of ISG15 by UBA7 E1 enzyme
eventOf	[Pathway:R-CEL-1169408] ISG15 antiviral mechanism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 enzyme - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-CEL-936552-5] Homologues of ISG15 [cytosol] [EntityWithAccessionedSequence:R-CEL-936550] uba-1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of ISG15 by UBA7 E1 enzyme
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-CEL-1169390] ISG15:UBA7 [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1169397
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1169408] ISG15 antiviral mechanism
(precedingEvent)	[Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8)
(inferredTo)	[Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 enzyme

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