Reactome | ubc-18 [cytosol]

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ubc-18 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10946231] ISG15 conjugating enzyme activity of UBE2L6 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CEL-9927400] UBE2L6:ISG15 E3 ligases [cytosol] - Caenorhabditis elegans [Complex:R-CEL-1169385] ISG15:UBCH8 [cytosol] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10943688
displayName	ubc-18 [cytosol]
endCoordinate	153
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-CEL-936554] E2 enzymes UbcH8/UBE1L [cytosol] - Caenorhabditis elegans
name	ubc-18 UBE2L6 Q21633
producedByEvent	[Reaction:R-CEL-1678843] ISGylation of protein translation regulator 4EHP - Caenorhabditis elegans [Reaction:R-CEL-1169406] ISGylation of host proteins - Caenorhabditis elegans [Reaction:R-CEL-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) - Caenorhabditis elegans [Reaction:R-CEL-1169402] ISGylation of E2 conjugating enzymes - Caenorhabditis elegans [Reaction:R-CEL-1169398] ISGylation of host protein filamin B - Caenorhabditis elegans [Reaction:R-CEL-9927247] ISGylation of DDX58 (RIG-I) - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9833973] ISGylation of PKR - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9833973] ISGylation of PKR - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9833973] ISGylation of PKR - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9833973] ISGylation of PKR - Caenorhabditis elegans
referenceEntity	[ReferenceGeneProduct:uniprot:Q21633] UniProt:Q21633
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-936014
startCoordinate	1

Referrals

(output)	[Reaction:R-CEL-9927247] ISGylation of DDX58 (RIG-I) [Reaction:R-CEL-1169406] ISGylation of host proteins [Reaction:R-CEL-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) [Reaction:R-CEL-1169402] ISGylation of E2 conjugating enzymes [Reaction:R-CEL-1169398] ISGylation of host protein filamin B [Reaction:R-CEL-1678843] ISGylation of protein translation regulator 4EHP [BlackBoxEvent:R-CEL-9833973] ISGylation of PKR
(hasComponent)	[Complex:R-CEL-9927400] UBE2L6:ISG15 E3 ligases [cytosol] [Complex:R-CEL-1169385] ISG15:UBCH8 [cytosol]
(hasMember)	[DefinedSet:R-CEL-936554] E2 enzymes UbcH8/UBE1L [cytosol]
(input)	[Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8)
(physicalEntity)	[CatalystActivity:10946231] ISG15 conjugating enzyme activity of UBE2L6 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol]