Reactome | ACLY tetramer transforms CIT to Ac-CoA

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ACLY tetramer transforms CIT to Ac-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10919434] ATP citrate synthase activity of ACLY tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10919441
displayName	ACLY tetramer transforms CIT to Ac-CoA
eventOf	[Pathway:R-CEL-75105] Fatty acyl-CoA biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA - Caenorhabditis elegans [Reaction:R-CEL-75851] Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA - Caenorhabditis elegans [Reaction:R-CEL-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76190] CIT [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACLY tetramer transforms CIT to Ac-CoA ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate Generation of Cytoplasmic Acetyl CoA from Citrate
output	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-76213] OA [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-CEL-75849] SLC25A1 exchanges CIT and MAL - Caenorhabditis elegans
regulatedBy	[PositiveRegulation:10919442] Positive regulation by 'MORC2 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-75848
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CEL-8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA [Reaction:R-CEL-75851] Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA [Reaction:R-CEL-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver)
(hasEvent)	[Pathway:R-CEL-75105] Fatty acyl-CoA biosynthesis
(inferredTo)	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA

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