Reactome | Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA

Schema > Reaction > Entries

Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10982946] acetyl-CoA carboxylase activity of Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10982948
displayName	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA
eventOf	[Pathway:R-CEL-200425] Carnitine shuttle - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:260763] fatty acid homeostasis
inferredFrom	[Reaction:R-HSA-8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-CEL-75848] ACLY tetramer transforms CIT to Ac-CoA - Caenorhabditis elegans
regulatedBy	[PositiveRegulation:R-HSA-539127] Positive regulation by 'CIT [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8876889
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-200425] Carnitine shuttle
(inferredTo)	[Reaction:R-HSA-8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA

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