Reactome | HMG CoA => acetoacetic acid + acetyl CoA

Schema > Reaction > Entries

HMG CoA => acetoacetic acid + acetyl CoA Show undefined attributes

catalystActivity	[CatalystActivity:10918444] hydroxymethylglutaryl-CoA lyase activity of HMGCL dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10918446
displayName	HMG CoA => acetoacetic acid + acetyl CoA
eventOf	[Pathway:R-CEL-77111] Synthesis of Ketone Bodies - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-74180] HMG CoA => acetoacetic acid + acetyl CoA - Homo sapiens
input	[SimpleEntity:R-ALL-73917] HMG CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	HMG CoA => acetoacetic acid + acetyl CoA
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-73909] ACA [mitochondrial matrix]
precedingEvent	[Reaction:R-CEL-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-74180
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-77111] Synthesis of Ketone Bodies
(inferredTo)	[Reaction:R-HSA-74180] HMG CoA => acetoacetic acid + acetyl CoA

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