Reactome | BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region

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BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10932155] lactate transmembrane transporter activity of BSG:MCTs [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10932159
displayName	BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
eventOf	[Pathway:R-CEL-433692] Proton-coupled monocarboxylate transport - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-CEL-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29708] LACT [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region lactate + H+ [cytosol] <=> lactate + H+ [extracellular]
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-373863] LACT [extracellular region]
precedingEvent	[Reaction:R-CEL-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-CEL-71849] LDH tetramer reduces PYR to LACT - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-373875
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-433692] Proton-coupled monocarboxylate transport
(precedingEvent)	[Reaction:R-CEL-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol [Reaction:R-CEL-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
(inferredTo)	[Reaction:R-HSA-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region

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