Reactome | 2MACA-CoA [mitochondrial matrix]

Schema > SimpleEntity > Entries

2MACA-CoA [mitochondrial matrix] Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
consumedByEvent	[FailedReaction:R-HSA-9915356] ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA - Homo sapiens [Reaction:R-PFA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Plasmodium falciparum [Reaction:R-DDI-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Caenorhabditis elegans [Reaction:R-DME-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Drosophila melanogaster [Reaction:R-GGA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Gallus gallus [Reaction:R-DRE-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Danio rerio [Reaction:R-SSC-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Sus scrofa [Reaction:R-BTA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Bos taurus [Reaction:R-CFA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Canis familiaris [Reaction:R-RNO-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Rattus norvegicus [Reaction:R-MMU-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Mus musculus [Reaction:R-DDI-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Dictyostelium discoideum [Reaction:R-CEL-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Caenorhabditis elegans [Reaction:R-DME-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Drosophila melanogaster [Reaction:R-GGA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Gallus gallus [Reaction:R-XTR-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Xenopus tropicalis [Reaction:R-DRE-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Danio rerio [Reaction:R-SSC-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Sus scrofa [Reaction:R-BTA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Bos taurus [Reaction:R-CFA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Canis familiaris [Reaction:R-RNO-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Rattus norvegicus [Reaction:R-MMU-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Mus musculus [Reaction:R-HSA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Homo sapiens [Reaction:R-HSA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Homo sapiens
crossReference	[DatabaseIdentifier:34500] COMPOUND:C03344
dbId	70836
displayName	2MACA-CoA [mitochondrial matrix]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
name	2MACA-CoA alpha-methylacetoacetyl-CoA 2-methylacetoacetyl-CoA
producedByEvent	[Reaction:R-DDI-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Gallus gallus [Reaction:R-XTR-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Danio rerio [Reaction:R-SSC-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Sus scrofa [Reaction:R-BTA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Bos taurus [Reaction:R-CFA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Canis familiaris [Reaction:R-RNO-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Mus musculus [Reaction:R-HSA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:57335] 2-methylacetoacetyl-CoA(4-) [ChEBI:57335]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-70836
updateTrackers	[UpdateTracker:9919549] Update Tracker - [SimpleEntity:70836] 2MACA-CoA [mitochondrial matrix] - v90:[add_removeReferenceEntity] [UpdateTracker:9892805] Update Tracker - [SimpleEntity:70836] 2MACA-CoA [mitochondrial matrix] - v54:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9919549] Update Tracker - [SimpleEntity:70836] 2MACA-CoA [mitochondrial matrix] - v90:[add_removeReferenceEntity] [UpdateTracker:9892805] Update Tracker - [SimpleEntity:70836] 2MACA-CoA [mitochondrial matrix] - v54:[addName]
(input)	[FailedReaction:R-HSA-9915356] ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA [Reaction:R-PFA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-DDI-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-CEL-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-DME-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-GGA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-DRE-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-SSC-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-BTA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-CFA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-RNO-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-MMU-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Reaction:R-DDI-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-CEL-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-DME-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-GGA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-XTR-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-DRE-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-SSC-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-BTA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-CFA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-RNO-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-MMU-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-HSA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-HSA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
(output)	[Reaction:R-DDI-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-CEL-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-DME-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-GGA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-XTR-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-DRE-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-SSC-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-BTA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-CFA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-RNO-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-MMU-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-HSA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+

© 2026 Reactome

Cite Us!