Reactome | PHF8 demethylates MeK21-histone H4

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PHF8 demethylates MeK21-histone H4 Show undefined attributes

catalystActivity	[CatalystActivity:10965727] histone demethylase activity of PHF8 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10965729
displayName	PHF8 demethylates MeK21-histone H4
eventOf	[Pathway:R-CEL-3214842] HDMs demethylate histones - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5423117] PHF8 demethylates MeK21-histone H4 - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [EntityWithAccessionedSequence:R-CEL-5423110] his-56 [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PHF8 demethylates MeK21-histone H4
output	[SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [EntityWithAccessionedSequence:R-CEL-181902] his-56 [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5423117
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3214842] HDMs demethylate histones
(inferredTo)	[Reaction:R-HSA-5423117] PHF8 demethylates MeK21-histone H4

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