Reactome | ZnT8 transports zinc into the Golgi apparatus

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ZnT8 transports zinc into the Golgi apparatus Show undefined attributes

catalystActivity	[CatalystActivity:10938191] zinc ion transmembrane transporter activity of SLC30A8 dimer [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10938193
displayName	ZnT8 transports zinc into the Golgi apparatus
eventOf	[Pathway:R-CEL-264876] Insulin processing - Caenorhabditis elegans [Pathway:R-CEL-435368] Zinc efflux and compartmentalization by the SLC30 family - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:6792028] zinc ion import into Golgi lumen
inferredFrom	[Reaction:R-HSA-437139] ZnT8 transports zinc into the Golgi apparatus - Homo sapiens
input	2 × [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ZnT8 transports zinc into the Golgi apparatus
output	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-216667] Zn2+ [Golgi lumen]
precedingEvent	[Reaction:R-CEL-442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-CEL-442317] ZIP6 and ZIP14 mediate zinc influx into cells - Caenorhabditis elegans [Reaction:R-CEL-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum - Caenorhabditis elegans [Reaction:R-CEL-442387] ZIP8 mediates zinc influx into cells - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-437139
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-264876] Insulin processing [Pathway:R-CEL-435368] Zinc efflux and compartmentalization by the SLC30 family
(inferredTo)	[Reaction:R-HSA-437139] ZnT8 transports zinc into the Golgi apparatus