Reactome | PAK1:ARHGEF6 complex binds G-protein beta-gamma complex

Schema > Reaction > Entries

PAK1:ARHGEF6 complex binds G-protein beta-gamma complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10985529
displayName	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex
eventOf	[Pathway:R-CEL-8964616] G beta:gamma signalling through CDC42 - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8964634] CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Homo sapiens
input	[Complex:R-CEL-9014578] Active PAK1:ARHGEF6 [cytosol] [Complex:R-CEL-167434] G-protein beta-gamma complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex
output	[Complex:R-CEL-9014575] G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane]
precedingEvent	[Reaction:R-CEL-8964619] PAK1 binds ARHGEF6 - Caenorhabditis elegans [Reaction:R-CEL-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Caenorhabditis elegans [Reaction:R-CEL-397835] Thrombin-activated PARs:Gq (active) dissociate - Caenorhabditis elegans [Reaction:R-CEL-749452] The Ligand:GPCR:Gq complex dissociates - Caenorhabditis elegans [Reaction:R-CEL-749454] The Ligand:GPCR:Gi complex dissociates - Caenorhabditis elegans [Reaction:R-CEL-751024] The Ligand:GPCR:Gz complex dissociates - Caenorhabditis elegans [Reaction:R-CEL-751019] The Ligand:GPCR:G12/13 complex dissociates - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8964605
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8964616] G beta:gamma signalling through CDC42
(precedingEvent)	[Reaction:R-CEL-8964634] CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
(inferredTo)	[Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex