Reactome | Retromer associates with WLS

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Retromer associates with WLS Show undefined attributes

category	binding
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10960308
displayName	Retromer associates with WLS
eventOf	[Pathway:R-CEL-3238698] WNT ligand biogenesis and trafficking - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CEL-3247836] Retromer recycles WLS to the Golgi - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-3247839] Retromer associates with WLS - Homo sapiens
input	[EntityWithAccessionedSequence:R-CEL-3247745] mig-14 [early endosome membrane] [EntityWithAccessionedSequence:R-CEL-3247743] snx-3 [cytosol] [Complex:R-CEL-3247737] VPS35:VPS29:VPS26 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Retromer associates with WLS
output	[Complex:R-CEL-3247845] WLS:retromer [early endosome membrane]
precedingEvent	[BlackBoxEvent:R-CEL-3247847] WLS is endocytosed to the early endosome - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3247839
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)	[BlackBoxEvent:R-CEL-3247836] Retromer recycles WLS to the Golgi
(inferredTo)	[Reaction:R-HSA-3247839] Retromer associates with WLS