Reactome | Retromer associates with WLS

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Retromer associates with WLS Show undefined attributes

authored	[InstanceEdit:3247883] Rothfels, K, 2013-04-05
category	binding
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:3247846] Rothfels, K, 2013-04-05
dbId	3247839
displayName	Retromer associates with WLS
edited	[InstanceEdit:3451017] Matthews, L, 2013-04-12
eventOf	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3247836] Retromer recycles WLS to the Golgi - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3247743] SNX3 [cytosol] [Complex:R-HSA-3247737] VPS35:VPS29:VPS26 [cytosol] [EntityWithAccessionedSequence:R-HSA-3247745] WLS [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3247703] Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex [LiteratureReference:3247734] SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless [LiteratureReference:3247717] The SNXy flavours of endosomal sorting [LiteratureReference:3247707] SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P [LiteratureReference:3247708] A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion [LiteratureReference:3247712] The retromer complex - endosomal protein recycling and beyond [LiteratureReference:3247702] Membrane transport: retromer to the rescue [LiteratureReference:3247706] Wingless secretion promotes and requires retromer-dependent cycling of Wntless [LiteratureReference:3247711] The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network [LiteratureReference:3247715] Wnt gradient formation requires retromer function in Wnt-producing cells
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Retromer associates with WLS
orthologousEvent	[Reaction:R-CEL-3247839] Retromer associates with WLS - Caenorhabditis elegans [Reaction:R-DME-3247839] Retromer associates with WLS - Drosophila melanogaster [Reaction:R-GGA-3247839] Retromer associates with WLS - Gallus gallus [Reaction:R-XTR-3247839] Retromer associates with WLS - Xenopus tropicalis [Reaction:R-SSC-3247839] Retromer associates with WLS - Sus scrofa [Reaction:R-BTA-3247839] Retromer associates with WLS - Bos taurus [Reaction:R-CFA-3247839] Retromer associates with WLS - Canis familiaris [Reaction:R-RNO-3247839] Retromer associates with WLS - Rattus norvegicus [Reaction:R-MMU-3247839] Retromer associates with WLS - Mus musculus
output	[Complex:R-HSA-3247845] WLS:retromer [early endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-3247847] WLS is endocytosed to the early endosome - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3247839
summation	[Summation:3247756] Retromer is a conserved multi-protein complex that is requir...

Referrals

(hasEvent)	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)	[BlackBoxEvent:R-HSA-3247836] Retromer recycles WLS to the Golgi

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