Reactome | botA HC disulfide bonded [synaptic vesicle membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:201753] synaptic vesicle membrane
componentOf	[Complex:R-CBO-5228950] botA HC:LC dimer [synaptic vesicle membrane] - Clostridium botulinum
created	[InstanceEdit:9616796] D'Eustachio, Peter, 2018-08-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	9616795
deleted	[Deleted:9616799] Deletion of instance: 181478
disease	[Disease:3632909] botulism
displayName	botA HC disulfide bonded [synaptic vesicle membrane]
endCoordinate	1296
goCellularComponent	[Compartment:5251407] host cell synaptic vesicle membrane
hasModifiedResidue	[InterChainCrosslinkedResidue:5228587] Inter-chain Crosslink via L-cystine (cross-link) at 454 and 430
inDisease	true
literatureReference	[LiteratureReference:5228581] Botulinum neurotoxin type A: cleavage of the heavy chain into two halves and their partial sequences [LiteratureReference:5228586] Partial amino acid sequence of the heavy and light chains of botulinum neurotoxin type A
maxDepth	1
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botA HC disulfide bonded BoNT/A HC disulfide bonded BoNT Heavy chain Type A
referenceEntity	[ReferenceGeneProduct:uniprot:P0DPI0] UniProt:P0DPI0 botA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:168825] Clostridium botulinum
stId	R-CBO-9616795
startCoordinate	449
updateTrackers	[UpdateTracker:9901810] Update Tracker - [EntityWithAccessionedSequence:9616795] botA HC disulfide bonded [synaptic vesicle membrane] - v75:[modifyName]

(updatedInstance)	[UpdateTracker:9901810] Update Tracker - [EntityWithAccessionedSequence:9616795] botA HC disulfide bonded [synaptic vesicle membrane] - v75:[modifyName]
(replacementInstances)	[Deleted:9616799] Deletion of instance: 181478
(hasComponent)	[Complex:R-CBO-5228950] botA HC:LC dimer [synaptic vesicle membrane]
(activeUnit)	[CatalystActivity:5244412] protein transmembrane transporter activity of botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]

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