botA HC disulfide bonded [synaptic vesicle membrane]

Stable Identifier
R-CBO-9616795
Type
Protein [EntityWithAccessionedSequence]
Species
Clostridium botulinum
Compartment
host cell synaptic vesicle membrane, synaptic vesicle membrane
Synonyms
BoNT/A HC disulfide bonded, BoNT Heavy chain Type A
GO Cellular Component
host cell synaptic vesicle membrane (0098585)
Icon
botA HC disulfide bonded [synaptic vesicle membrane] icon
botA HC disulfide bonded [synaptic vesicle membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
6370252 Partial amino acid sequence of the heavy and light chains of botulinum neurotoxin type A

Schmidt, JJ, Sathyamoorthy, V, DasGupta, BR

Biochem. Biophys. Res. Commun. 1984
3178218 Botulinum neurotoxin type A: cleavage of the heavy chain into two halves and their partial sequences

Sathyamoorthy, V, DasGupta, BR, Foley, J, Niece, RL

Arch. Biochem. Biophys. 1988
External Reference Information
External Reference
UniProt:P0DPI0 botA
Gene Names
botA, atx, bonT
Chain
initiator methionine:1, chain:2-1296, chain:2-448, chain:449-1296
Reference Genes
BioGPS Gene:56879027 botA
Monarch:56879027 botA
NCBI Gene:56879027 botA
Reference Transcript
Participates
as a component of
Other forms of this molecule
botA HC disulfide bonded [plasma membrane]
botA LC disulfide bonded [plasma membrane]
botA HC [synaptic vesicle membrane]
botA LC disulfide bonded [synaptic vesicle membrane]
botA LC [cytosol]
botA HC disulfide bonded [extracellular region]
botA LC disulfide bonded [extracellular region]
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 454 and 430
Coordinate
454
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Cross References
RefSeq
PDB
Interactors (3)
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