Reactome | botE HC [synaptic vesicle membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:201753] synaptic vesicle membrane
created	[InstanceEdit:5228949] D'Eustachio, Peter, 2014-01-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5228952
disease	[Disease:3632909] botulism
displayName	botE HC [synaptic vesicle membrane]
endCoordinate	1251
goCellularComponent	[Compartment:5251407] host cell synaptic vesicle membrane
inDisease	true
literatureReference	[LiteratureReference:5228677] Botulinum neurotoxin type E fragmented with endoproteinase Lys-C reveals the site trypsin nicks and homology with tetanus neurotoxin
maxDepth	1
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botE HC BoNT/E HC BoNT Heavy chain Type E
producedByEvent	[BlackBoxEvent:R-HSA-5244506] botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q00496] UniProt:Q00496 botE
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:168825] Clostridium botulinum
stId	R-CBO-5228952
startCoordinate	423
updateTrackers	[UpdateTracker:9901773] Update Tracker - [EntityWithAccessionedSequence:5228952] botE HC [synaptic vesicle membrane] - v75:[modifyName]

(updatedInstance)	[UpdateTracker:9901773] Update Tracker - [EntityWithAccessionedSequence:5228952] botE HC [synaptic vesicle membrane] - v75:[modifyName]
(output)	[BlackBoxEvent:R-HSA-5244506] botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol

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