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botE HC [synaptic vesicle membrane]
Stable Identifier
R-CBO-5228952
Type
Protein [EntityWithAccessionedSequence]
Species
Clostridium botulinum
Compartment
synaptic vesicle membrane
Synonyms
BoNT/E HC, BoNT Heavy chain Type E
GO Cellular Component
host cell synaptic vesicle membrane
(0098585)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type E (botE) (Homo sapiens)
botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
botE HC [synaptic vesicle membrane] (Clostridium botulinum)
Literature References
PubMed ID
Title
Journal
Year
2116911
Botulinum neurotoxin type E fragmented with endoproteinase Lys-C reveals the site trypsin nicks and homology with tetanus neurotoxin
Giménez, JA
,
DasGupta, BR
Biochimie
1990
External Reference Information
External Reference
UniProt:Q00496 botE
Gene Names
botE
Chain
initiator methionine:1, chain:2-1251, chain:2-422, chain:423-1251
Reference Genes
KEGG:ag:CAA43999 botE
UCSC:Q00496 botE
Participates
as an output of
botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
Other forms of this molecule
botE LC disulfide bonded [plasma membrane]
botE HC disulfide bonded [plasma membrane]
botE LC disulfide bonded [synaptic vesicle membrane]
botE HC disulfide bonded [synaptic vesicle membrane]
botE LC [cytosol]
botE LC disulfide bonded [extracellular region]
botE HC disulfide bonded [extracellular region]
Disease
Name
Identifier
Synonyms
botulism
DOID:11976
Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Cross References
Mondo
0005498
PDB
7K7Y
,
1ZL5
,
1ZKX
,
1T3A
,
1ZKW
,
1ZL6
,
1ZN3
,
1T3C
,
7UIA
,
3FFZ
,
9ARJ
,
9ARK
,
7QFP
,
7K84
,
7UIB
,
7UIE
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