Reactome | botE HC disulfide bonded [plasma membrane]

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botE HC disulfide bonded [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CBO-5228955] BoNT/E HC:LC dimer [plasma membrane] - Clostridium botulinum
created	[InstanceEdit:181561] Gopinathrao, G, 2006-06-14 16:40:11
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	181571
deleted	[Deleted:5251010] Deletion of instance: 181563
disease	[Disease:3632909] botulism
displayName	botE HC disulfide bonded [plasma membrane]
endCoordinate	1251
goCellularComponent	[GO_CellularComponent:6485] host cell plasma membrane
hasModifiedResidue	[InterChainCrosslinkedResidue:5228672] Inter-chain Crosslink via L-cystine (cross-link) at 426 and 412
inDisease	true
literatureReference	[LiteratureReference:5228677] Botulinum neurotoxin type E fragmented with endoproteinase Lys-C reveals the site trypsin nicks and homology with tetanus neurotoxin
maxDepth	1
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botE HC disulfide bonded BoNT/E HC disulfide bonded BoNT Heavy chain Type E
referenceEntity	[ReferenceGeneProduct:uniprot:Q00496] UniProt:Q00496 botE
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:168825] Clostridium botulinum
stId	R-CBO-181571
startCoordinate	423
updateTrackers	[UpdateTracker:9901688] Update Tracker - [EntityWithAccessionedSequence:181571] botE HC disulfide bonded [plasma membrane] - v75:[modifyName] [UpdateTracker:9889215] Update Tracker - [EntityWithAccessionedSequence:181571] botE HC disulfide bonded [plasma membrane] - v48:[addDisease, addHasModifiedResidue, addLiteratureReference, addName, modifyEndCoordinate, modifyStartCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9901688] Update Tracker - [EntityWithAccessionedSequence:181571] botE HC disulfide bonded [plasma membrane] - v75:[modifyName] [UpdateTracker:9889215] Update Tracker - [EntityWithAccessionedSequence:181571] botE HC disulfide bonded [plasma membrane] - v48:[addDisease, addHasModifiedResidue, addLiteratureReference, addName, modifyEndCoordinate, modifyStartCoordinate]
(replacementInstances)	[Deleted:5251010] Deletion of instance: 181563
(hasComponent)	[Complex:R-CBO-5228955] BoNT/E HC:LC dimer [plasma membrane]

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