Reactome | Lanosterol biosynthesis

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Lanosterol biosynthesis Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443970
displayName	Lanosterol biosynthesis
eventOf	[Pathway:R-BTA-191273] Cholesterol biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20521] cholesterol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Bos taurus [Reaction:R-BTA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Bos taurus [Reaction:R-BTA-191352] HMGCR dimer reduces bHMG-CoA to MVA - Bos taurus [Reaction:R-BTA-9705584] HMGCR dimer binds statins - Bos taurus [Reaction:R-BTA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - Bos taurus [Reaction:R-BTA-191422] Mevalonate-5-phosphate is further phosphorylated - Bos taurus [Reaction:R-BTA-191414] MVD decarboxylates MVA5PP to IPPP - Bos taurus [Reaction:R-BTA-191382] Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate - Bos taurus [Reaction:R-BTA-9717834] GGPS1 hexamer transfers IPPP to DMAPP - Bos taurus [Reaction:R-BTA-9717830] GGPS1 hexamer transfers IPPP to GPP - Bos taurus [Reaction:R-BTA-191405] Two FAPP molecules dimerize to form presqualene diphosphate - Bos taurus [Reaction:R-BTA-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate - Bos taurus [Reaction:R-BTA-191402] Reduction of presqualene diphosphate to form squalene - Bos taurus [Reaction:R-BTA-191299] Squalene is oxidized to its epoxide - Bos taurus [Reaction:R-BTA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Bos taurus
inferredFrom	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Lanosterol biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-9969896
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-191273] Cholesterol biosynthesis
(inferredTo)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis

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