Reactome | GGPS1 hexamer transfers IPPP to GPP

Schema > Reaction > Entries

GGPS1 hexamer transfers IPPP to GPP Show undefined attributes

catalystActivity	[CatalystActivity:10435552] (2E,6E)-farnesyl diphosphate synthase activity of holo-GGPS1 hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10435554
displayName	GGPS1 hexamer transfers IPPP to GPP
eventOf	[Pathway:R-BTA-9969896] Lanosterol biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-191405] Two FAPP molecules dimerize to form presqualene diphosphate - Bos taurus
inferredFrom	[Reaction:R-HSA-9717830] GGPS1 hexamer transfers IPPP to GPP - Homo sapiens
input	[SimpleEntity:R-ALL-191409] GPP [cytosol] [SimpleEntity:R-ALL-191362] IPPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GGPS1 hexamer transfers IPPP to GPP isopentenyl diphosphate + (2E)-geranyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
output	[SimpleEntity:R-ALL-191385] FAPP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-BTA-9717834] GGPS1 hexamer transfers IPPP to DMAPP - Bos taurus [Reaction:R-BTA-191414] MVD decarboxylates MVA5PP to IPPP - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9717830
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-BTA-191405] Two FAPP molecules dimerize to form presqualene diphosphate
(inferredTo)	[Reaction:R-HSA-9717830] GGPS1 hexamer transfers IPPP to GPP

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