Reactome | factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)

Schema > Reaction > Entries

factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10341690] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10440976
displayName	factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)
eventOf	[Pathway:R-BTA-9769735] Initiation of coagulation cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 - Bos taurus [Reaction:R-BTA-9930792] factor Va intermediate -> factor Va - Bos taurus [Reaction:R-BTA-9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa - Bos taurus
inferredFrom	[Reaction:R-HSA-9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-140697] F5 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)
output	[EntityWithAccessionedSequence:R-BTA-9930787] F5 [extracellular region] [Complex:R-BTA-9930795] factor Va intermediate [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9930790
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 [Reaction:R-BTA-9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa [Reaction:R-BTA-9930792] factor Va intermediate -> factor Va
(hasEvent)	[Pathway:R-BTA-9769735] Initiation of coagulation cascade
(inferredTo)	[Reaction:R-HSA-9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)

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