Reactome | factor Va intermediate -> factor Va

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factor Va intermediate -> factor Va Show undefined attributes

catalystActivity	[CatalystActivity:10341690] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10440984
displayName	factor Va intermediate -> factor Va
eventOf	[Pathway:R-BTA-9769735] Initiation of coagulation cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Bos taurus
inferredFrom	[Reaction:R-HSA-9930792] factor Va intermediate -> factor Va - Homo sapiens
input	[Complex:R-BTA-9930795] factor Va intermediate [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor Va intermediate -> factor Va FVa intermediate -> FVa
output	[EntityWithAccessionedSequence:R-BTA-9933750] F5 [extracellular region] [Complex:R-BTA-140692] factor Va [extracellular region]
precedingEvent	[Reaction:R-BTA-9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) - Bos taurus [Reaction:R-BTA-9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) - Bos taurus [Reaction:R-BTA-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Bos taurus
regulatedBy	[NegativeRegulation:10440985] Negative regulation by 'TFPI?:FV intermediate:PROS1 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9930792
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-BTA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase)
(inferredTo)	[Reaction:R-HSA-9930792] factor Va intermediate -> factor Va