Reactome | PTPRJ dephosphorylates active FLT3

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PTPRJ dephosphorylates active FLT3 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:6807009] protein tyrosine phosphatase activity of PTPRJ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9698406] Rothfels, Karen, 2020-08-26
dbId	9698408
displayName	PTPRJ dephosphorylates active FLT3
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
input	[Complex:R-HSA-9604751] Active FLT3 [plasma membrane] 8 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9697866] Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling [LiteratureReference:9698778] Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML [LiteratureReference:9698735] NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases [LiteratureReference:9698765] Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ [LiteratureReference:9698736] Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia [LiteratureReference:9698776] NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells [LiteratureReference:9698748] NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML
modified	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
name	PTPRJ dephosphorylates active FLT3
orthologousEvent	[Reaction:R-BTA-9698408] PTPRJ dephosphorylates active FLT3 - Bos taurus [Reaction:R-CFA-9698408] PTPRJ dephosphorylates active FLT3 - Canis familiaris [Reaction:R-MMU-9698408] PTPRJ dephosphorylates active FLT3 - Mus musculus
output	[Complex:R-HSA-9698407] p-Y768,Y969 FLT3 dimer:FLT3LG dimer [plasma membrane] 8 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Homo sapiens
regulatedBy	[NegativeRegulation:9702479] Negative regulation by 'H2O2 [cytosol]'
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9698408
summation	[Summation:9698404] The protein tyrosine phosphatase PTPRJ (also known as DEP1) ...

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(hasEvent)

[Pathway:R-HSA-9706369] Negative regulation of FLT3